Alpha 2-adrenoceptor participates in anti-hyperalgesia by regulating metabolic demand

The α2-adrenoceptor agonist dexmedetomidine is a commonly used drug for sedatives in clinics and has analgesic effects; however, its mechanism of analgesia in the spine remains unclear. In this study, we systematically used behavioural and transcriptomic sequencing, pharmacological intervention, ele...

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Bibliographic Details
Main Authors: Ke Zhang, Yu-Qing Ren, Yan Xue, Dongxia Duan, Tong Zhou, Ying-Zhuo Ding, Xiang Li, Wan-Kun Gong, Jiao-Qiong Guan, Le Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1359319/full