Effects of Roxadustat on Erythropoietin Production in the Rat Body

Effects of Roxadustat on Erythropoietin Production in the Rat Body

Anemia is a major complication of chronic renal failure. To treat this anemia, prolylhydroxylase domain enzyme (PHD) inhibitors as well as erythropoiesis-stimulating agents (ESAs) have been used. Although PHD inhibitors rapidly stimulate erythropoietin (Epo) production, the precise sites of Epo prod...

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Bibliographic Details
Main Authors: Yukiko Yasuoka, Yuichiro Izumi, Takashi Fukuyama, Haruki Omiya, Truyen D. Pham, Hideki Inoue, Tomomi Oshima, Taiga Yamazaki, Takayuki Uematsu, Noritada Kobayashi, Yoshitaka Shimada, Yasushi Nagaba, Tetsuro Yamashita, Masashi Mukoyama, Yuichi Sato, Susan M. Wall, Jeff M. Sands, Noriko Takahashi, Katsumasa Kawahara, Hiroshi Nonoguchi
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
erythropoietin
PHD inhibitor
Roxadustat
hypoxia
deglycosylation
Western blotting
Online Access:https://www.mdpi.com/1420-3049/27/3/1119

Internet

https://www.mdpi.com/1420-3049/27/3/1119

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