Species-Specific Chromosome Engineering Greatly Improves Fully Human Polyclonal Antibody Production Profile in Cattle.

Species-Specific Chromosome Engineering Greatly Improves Fully Human Polyclonal Antibody Production Profile in Cattle.

Large-scale production of fully human IgG (hIgG) or human polyclonal antibodies (hpAbs) by transgenic animals could be useful for human therapy. However, production level of hpAbs in transgenic animals is generally very low, probably due to the fact that evolutionarily unique interspecies-incompatib...

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Bibliographic Details
Main Authors: Hiroaki Matsushita, Akiko Sano, Hua Wu, Zhongde Wang, Jin-An Jiao, Poothappillai Kasinathan, Eddie J Sullivan, Yoshimi Kuroiwa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4479556?pdf=render

Internet

http://europepmc.org/articles/PMC4479556?pdf=render

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