The Marine-Derived Macrolactone Mandelalide A Is an Indirect Activator of AMPK

The Marine-Derived Macrolactone Mandelalide A Is an Indirect Activator of AMPK

The mandelalides are complex macrolactone natural products with distinct macrocycle motifs and a bioactivity profile that is heavily influenced by compound glycosylation. Mandelalides A and B are direct inhibitors of mitochondrial ATP synthase (complex V) and therefore more toxic to mammalian cells...

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Bibliographic Details
Main Authors: Daphne R. Mattos, Xuemei Wan, Jeffrey D. Serrill, Minh H. Nguyen, Ian R. Humphreys, Benoit Viollet, Amos B. Smith, Kerry L. McPhail, Jane E. Ishmael
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Marine Drugs
Subjects:
OXPHOS
polyketide
ATP synthase
ATPase
oxidative phosphorylation
AMP-activated protein kinase
Online Access:https://www.mdpi.com/1660-3397/20/7/418

Internet

https://www.mdpi.com/1660-3397/20/7/418

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