The inactive X chromosome accumulates widespread epigenetic variability with age

The inactive X chromosome accumulates widespread epigenetic variability with age

Abstract Background Loss of epigenetic control is a hallmark of aging. Among the most prominent roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome in females through DNA methylation. Hence, age-related disruption of X-chromosome inactivation (XCI) may contrib...

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Bibliographic Details
Main Authors: Yunfeng Liu, Lucy Sinke, Thomas H. Jonkman, Roderick C. Slieker, BIOS Consortium, Erik W. van Zwet, Lucia Daxinger, Bastiaan T. Heijmans
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
Aging
X chromosome
Women
Variance
Gene expression
Online Access:https://doi.org/10.1186/s13148-023-01549-y

Internet

https://doi.org/10.1186/s13148-023-01549-y

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