Signal execution modes emerge in biochemical reaction networks calibrated to experimental data

Summary: Mathematical models of biomolecular networks are commonly used to study cellular processes; however, their usefulness to explain and predict dynamic behaviors is often questioned due to the unclear relationship between parameter uncertainty and network dynamics. In this work, we introduce P...

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Bibliographic Details
Main Authors: Oscar O. Ortega, Mustafa Ozen, Blake A. Wilson, James C. Pino, Michael W. Irvin, Geena V. Ildefonso, Shawn P. Garbett, Carlos F. Lopez
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224012148