Prognostic impact of HER2 biomarker levels in trastuzumab-treated early HER2-positive breast cancer

Prognostic impact of HER2 biomarker levels in trastuzumab-treated early HER2-positive breast cancer

Abstract Background Overexpression of human epidermal growth factor receptor 2 (HER2) caused by HER2 gene amplification is a driver in breast cancer tumorigenesis. We aimed to investigate the prognostic significance of manual scoring and digital image analysis (DIA) algorithm assessment of HER2 copy...

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Bibliographic Details
Main Authors: Caroline Rönnlund, Emmanouil G. Sifakis, Caroline Schagerholm, Qiao Yang, Emelie Karlsson, Xinsong Chen, Theodoros Foukakis, Jodi Weidler, Michael Bates, Irma Fredriksson, Stephanie Robertson, Johan Hartman
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Breast Cancer Research
Subjects:
Breast cancer
HER2
ERBB2 mRNA
Digital image analysis
Prognosis
Online Access:https://doi.org/10.1186/s13058-024-01779-9

Internet

https://doi.org/10.1186/s13058-024-01779-9

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