Phosphorylation state of the histone variant H2A.X controls human stem and progenitor cell fate decisions

Phosphorylation state of the histone variant H2A.X controls human stem and progenitor cell fate decisions

Summary: Histone variants (HVs) are a subfamily of epigenetic regulators implicated in embryonic development, but their role in human stem cell fate remains unclear. Here, we reveal that the phosphorylation state of the HV H2A.X (γH2A.X) regulates self-renewal and differentiation of human pluripoten...

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Bibliographic Details
Main Authors: Luca Orlando, Borko Tanasijevic, Mio Nakanishi, Jennifer C. Reid, Juan L. García-Rodríguez, Kapil Dev Chauhan, Deanna P. Porras, Lili Aslostovar, Justin D. Lu, Zoya Shapovalova, Ryan R. Mitchell, Allison L. Boyd, Mickie Bhatia
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
pluripotent stem cells
histone variants
self-renewal
differentiation
epigenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721001327

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http://www.sciencedirect.com/science/article/pii/S2211124721001327

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