Neutrophil elastase activates the release of extracellular traps from COPD blood monocyte‐derived macrophages

Abstract Neutrophil elastase (NE), a major inflammatory mediator in chronic obstructive pulmonary disease (COPD) airways, impairs macrophage function, contributing to persistence of airway inflammation. We hypothesized that NE activates a novel mechanism of macrophage‐induced inflammation: release o...

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Bibliographic Details
Main Authors: Shuo Zheng, Apparao B. Kummarapurugu, Gamze B. Bulut, Aamer Syed, Le Kang, Judith A. Voynow
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13671