Inhibition of CXCR2 enhances CNS remyelination via modulating PDE10A/cAMP signaling pathway

Inhibition of CXCR2 enhances CNS remyelination via modulating PDE10A/cAMP signaling pathway

CXC chemokine receptor 2 (CXCR2) plays an important role in demyelinating diseases, but the detailed mechanisms were not yet clarified. In the present study, we mainly investigated the critical function and the potential molecular mechanisms of CXCR2 on oligodendrocyte precursor cell (OPC) different...

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Bibliographic Details
Main Authors: Cheng Ju, Fangyu Yuan, Lu Wang, Caixia Zang, Jingwen Ning, Meiyu Shang, Jingwei Ma, Gen Li, Yang Yang, Qiuzhu Chen, Yueqi Jiang, Fangfang Li, Xiuqi Bao, Dan Zhang
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Neurobiology of Disease
Subjects:
CXC chemokine receptor 2
Oligodendrocytes
Remyelination
Phosphodiesterase 10A
Ethidium bromide
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123000025

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http://www.sciencedirect.com/science/article/pii/S0969996123000025

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