Physiological DNA damage promotes functional endoreplication of mammary gland alveolar cells during lactation
Abstract Lactation insufficiency affects many women worldwide. During lactation, a large portion of mammary gland alveolar cells become polyploid, but how these cells balance the hyperproliferation occurring during normal alveologenesis with terminal differentiation required for lactation is unknown...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Sprog: | English |
| Udgivet: |
Nature Portfolio
2024-04-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/s41467-024-47668-9 |