Cefiderocol Protects against Cytokine- and Endotoxin-Induced Disruption of Vascular Endothelial Cell Integrity in an In Vitro Experimental Model

Cefiderocol Protects against Cytokine- and Endotoxin-Induced Disruption of Vascular Endothelial Cell Integrity in an In Vitro Experimental Model

The severe course of bloodstream infections with Gram-negative bacilli can lead to organ dysfunctions and compromise the integrity of the vascular barrier, which are the hallmarks of sepsis. This study aimed to investigate the potential effect of cefiderocol on the barrier function of vascular endot...

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Bibliographic Details
Main Authors: Dagmar Hildebrand, Jana Böhringer, Eva Körner, Ute Chiriac, Sandra Förmer, Aline Sähr, Torsten Hoppe-Tichy, Klaus Heeg, Dennis Nurjadi
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Antibiotics
Subjects:
cefiderocol
beta-lactam antibiotic
endothelial barrier
vascular leakage
Online Access:https://www.mdpi.com/2079-6382/11/5/581

Internet

https://www.mdpi.com/2079-6382/11/5/581

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