Protective effects of dexmedetomidine on cerebral ischemia/reperfusion injury via the microRNA-214/ROCK1/NF-κB axis

Protective effects of dexmedetomidine on cerebral ischemia/reperfusion injury via the microRNA-214/ROCK1/NF-κB axis

Abstract Background Cerebral ischemia/reperfusion injury (CIRI) is a complication of surgical procedure associated with high mortality. The protective effect of dexmedetomidine (DEX) on CIRI has been explored in previous works, yet the underlying molecular mechanism remains unclear. Our study explor...

Full description

Bibliographic Details
Main Authors: Wenyi Liu, Cuihua Shao, Chuanshan Zang, Jian Sun, Min Xu, Yuna Wang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Anesthesiology
Subjects:
Cerebral ischemia/reperfusion injury
Dexmedetomidine
microRNA-214
Rho-associated kinase 1
NF-κB
Online Access:https://doi.org/10.1186/s12871-021-01423-5

Internet

https://doi.org/10.1186/s12871-021-01423-5

Similar Items