METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing

METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing

Abstract Background Endometriosis (EMs), the ectopic planting of functional endometrium outside of the uterus, is a leading cause of infertility and pelvic pain. As a fundamental mRNA modification, N6-methyladenosine (m6A) participates in various pathological processes. However, the role of m6A RNA...

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Bibliographic Details
Main Authors: Xiaotong Wang, Jing Wang, Xibo Zhao, Han Wu, Jixin Li, Yan Cheng, Qiuyan Guo, Xuejiao Cao, Tian Liang, Liyuan Sun, Guangmei Zhang
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Translational Medicine
Subjects:
METTL3
SIRT1
Endometriosis
m6A
Epigenetic modification
Cellular senescence
Online Access:https://doi.org/10.1186/s12967-023-04209-0

Internet

https://doi.org/10.1186/s12967-023-04209-0

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