Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5

Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5

ABSTRACT It has recently emerged that HIV-1 Nef counteracts the antiviral host proteins SERINC3 and SERINC5. In particular, SERINC5 inhibits the infectivity of progeny virions when incorporated. SERINC3 and SERINC5 are also counteracted by the unrelated murine leukemia virus glycosylated Gag (glycoG...

Full description

Bibliographic Details
Main Authors: Yuanfei Wu, Balaji Olety, Eric R. Weiss, Elena Popova, Hikaru Yamanaka, Heinrich Göttlinger
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mBio
Subjects:
Nef
SERINC5
human immunodeficiency virus
infectivity
virus replication
Online Access:https://journals.asm.org/doi/10.1128/mBio.01071-19

Internet

https://journals.asm.org/doi/10.1128/mBio.01071-19

Similar Items