Gram-Scale Preparation of Cannflavin A from Hemp (<i>Cannabis sativa</i> L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase

Gram-Scale Preparation of Cannflavin A from Hemp (<i>Cannabis sativa</i> L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase

Inhibitors targeting kynurenine-3-monooxygenase (KMO), an enzyme in the neurotoxic kynurenine pathway (KP), are potential therapeutics for KP metabolites-mediated neuroinflammatory and neurodegenerative disorders. Although phytochemicals from <i>Cannabis</i> (<i>C. sativa</i>...

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Bibliographic Details
Main Authors: Tess Puopolo, Tanran Chang, Chang Liu, Huifang Li, Xu Liu, Xian Wu, Hang Ma, Navindra P. Seeram
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Biology
Subjects:
<i>Cannabis sativa</i> L.
cannflavin A
kynurenine pathway
tryptophan
inflammation
neurodegeneration
Online Access:https://www.mdpi.com/2079-7737/11/10/1416

Internet

https://www.mdpi.com/2079-7737/11/10/1416

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