Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus

Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus

Successful oncolytic virus treatment of malignant glioblastoma multiforme depends on widespread tumor-specific lytic virus replication and escape from mitigating innate immune responses to infection. Here we characterize a new HSV vector, JD0G, that is deleted for ICP0 and the joint sequences separ...

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Bibliographic Details
Main Authors: Bonnie Reinhart, Lucia Mazzacurati, Adriana Forero, Chang-Sook Hong, Junichi Eguchi, Hideho Okada, Wendy Fellows, Ajay Niranjan, Justus B. Cohen, Joseph C. Glorioso, Paola Grandi
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Advances in Virology
Online Access:http://dx.doi.org/10.1155/2012/815465

Internet

http://dx.doi.org/10.1155/2012/815465

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