Involvement of the TGF-β Signaling Pathway in the Development of YAP-Driven Osteosarcoma Lung Metastasis

Involvement of the TGF-β Signaling Pathway in the Development of YAP-Driven Osteosarcoma Lung Metastasis

BackgroundThe poor survival rate of patients with osteosarcoma (OS), specifically with metastases at diagnosis, undergoes the urgency to develop new therapeutic strategies. Although we recently demonstrated the key role of YAP/TEAD signaling in the growth of OS primary tumor, the molecular mechanism...

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Bibliographic Details
Main Authors: Sarah Morice, Geoffroy Danieau, Robel Tesfaye, Mathilde Mullard, Régis Brion, Maryne Dupuy, Benjamin Ory, Bénédicte Brounais-Le Royer, Isabelle Corre, Françoise Redini, Franck Verrecchia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Oncology
Subjects:
osteosarcoma
lung metastases
Hippo
YAP
TEAD
TGF-β/Smad3
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.765711/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.765711/full

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