Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregation

Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregation

Lipolytic modification of LDL particles by SMase generates LDL aggregates with a strong affinity for human arterial proteoglycans and may so enhance LDL retention in the arterial wall. Here, we evaluated the effects of apoA-I mimetic peptide 4F on structural and functional properties of the SMase-mo...

Full description

Bibliographic Details
Main Authors: Su Duy Nguyen, Matti Javanainen, Sami Rissanen, Hongxia Zhao, Jenni Huusko, Annukka M. Kivelä, Seppo Ylä-Herttuala, Mohamad Navab, Alan M. Fogelman, Ilpo Vattulainen, Petri T. Kovanen, Katariina Öörni
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Journal of Lipid Research
Subjects:
low density lipoprotein
apolipoprotein B-100
proteoglycans
retention
atherosclerosis
conformation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520317314

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520317314

Similar Items