Targeting <i>Penicillium expansum</i> GMC Oxidoreductase with High Affinity Small Molecules for Reducing Patulin Production

Targeting <i>Penicillium expansum</i> GMC Oxidoreductase with High Affinity Small Molecules for Reducing Patulin Production

Flavine adenine dinucleotide (FAD) dependent glucose methanol choline oxidoreductase (GMC oxidoreductase) is the terminal key enzyme of the patulin biosynthetic pathway. GMC oxidoreductase catalyzes the oxidative ring closure of (<i>E</i>)-ascladiol to patulin. Currently, no protein invo...

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Bibliographic Details
Main Authors: Vincenzo Tragni, Pietro Cotugno, Anna De Grassi, Maria Maddalena Cavalluzzi, Annamaria Mincuzzi, Giovanni Lentini, Simona Marianna Sanzani, Antonio Ippolito, Ciro Leonardo Pierri
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biology
Subjects:
<i>Penicillium expansum</i> GMC oxidoreductase
patulin biosynthesis
contamination prevention
mycotoxin production inhibition
comparative 3D modeling
virtual screening of chemical libraries
Online Access:https://www.mdpi.com/2079-7737/10/1/21

Internet

https://www.mdpi.com/2079-7737/10/1/21

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