Oxidative Stress-Induced Growth Inhibitor (OSGIN1), a Target of X-Box-Binding Protein 1, Protects Palmitic Acid-Induced Vascular Lipotoxicity through Maintaining Autophagy

Oxidative Stress-Induced Growth Inhibitor (OSGIN1), a Target of X-Box-Binding Protein 1, Protects Palmitic Acid-Induced Vascular Lipotoxicity through Maintaining Autophagy

Saturated free fatty acids (FFAs) strongly correlate with metabolic syndromes and are well-known risk factors for cardiovascular diseases (CVDs). The mechanism of palmitic acid (PA)-induced vascular lipotoxicity under endoplasmic reticulum (ER) stress is unknown. In the present paper, we investigate...

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Bibliographic Details
Main Authors: Chong-Sun Khoi, Cai-Qin Xiao, Kuan-Yu Hung, Tzu-Yu Lin, Chih-Kang Chiang
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomedicines
Subjects:
palmitic acid
OSGIN1
unfolded protein response
XBP1s
autophagy
eNOS
Online Access:https://www.mdpi.com/2227-9059/10/5/992

Internet

https://www.mdpi.com/2227-9059/10/5/992

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