JOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression

JOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression

Abstract Pyruvate kinase M2 (PKM2) plays an important role in the metabolism and proliferation of leukemia cells. Here, we show that deubiquitinase JOSD2, a novel tumor suppressor, blocks PKM2 nuclear localization by reducing its K433 acetylation in acute myeloid leukemia (AML). Firstly, we show tha...

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Bibliographic Details
Main Authors: Hu Lei, Li Yang, Yingying Wang, Zhihui Zou, Meng Liu, Hanzhang Xu, Yingli Wu
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Experimental Hematology & Oncology
Subjects:
JOSD2
PKM2
Acute myeloid leukemia
Nuclear localization
Online Access:https://doi.org/10.1186/s40164-022-00295-w

Internet

https://doi.org/10.1186/s40164-022-00295-w

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