Impaired in vitro Interferon-γ production in patients with visceral leishmaniasis is improved by inhibition of PD1/PDL-1 ligation.

Impaired in vitro Interferon-γ production in patients with visceral leishmaniasis is improved by inhibition of PD1/PDL-1 ligation.

Visceral leishmaniasis (VL) is a neglected tropical disease that causes substantial morbidity and mortality and is a growing health problem in Ethiopia, where this study took place. Most individuals infected with Leishmania donovani parasites will stay asymptomatic, but some develop VL that, if left...

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Bibliographic Details
Main Authors: Yegnasew Takele, Emebet Adem, Susanne Ursula Franssen, Rebecca Womersley, Myrsini Kaforou, Michael Levin, Ingrid Müller, James Anthony Cotton, Pascale Kropf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0010544

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https://doi.org/10.1371/journal.pntd.0010544

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