Shark Variable New Antigen Receptor (VNAR) Single Domain Antibody Fragments: Stability and Diagnostic Applications

Shark Variable New Antigen Receptor (VNAR) Single Domain Antibody Fragments: Stability and Diagnostic Applications

The single variable new antigen receptor domain antibody fragments (VNARs) derived from shark immunoglobulin new antigen receptor antibodies (IgNARs) represent some of the smallest known immunoglobulin-based protein scaffolds. As single domains, they demonstrate favorable size and cryptic epitope re...

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Bibliographic Details
Main Authors: Stewart Nuttall, Matthew A. Perugini, Iveth González, Joanne L. Casey, Abdulmonem Sanalla, Miles Barraclough, Con Dogovski, Julie Angerosa, Kathy Parisi, Olan Dolezal, Katherine Griffiths, Michael Foley
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Antibodies
Subjects:
single-domain antibody
shark VNAR
thermal stability
pH stability
protease resistance
AMA-1
Plasmodium
malaria
diagnosis
Online Access:http://www.mdpi.com/2073-4468/2/1/66

Internet

http://www.mdpi.com/2073-4468/2/1/66

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