Koumine inhibits IL-1β-induced chondrocyte inflammation and ameliorates extracellular matrix degradation in osteoarthritic cartilage through activation of PINK1/Parkin-mediated mitochondrial autophagy

Koumine inhibits IL-1β-induced chondrocyte inflammation and ameliorates extracellular matrix degradation in osteoarthritic cartilage through activation of PINK1/Parkin-mediated mitochondrial autophagy

Osteoarthritis (OA) is a degenerative joint disease, Increasingly, mitochondrial autophagy has been found to play an important regulatory role in the prevention and treatment of osteoarthritis. Koumine is a bioactive alkaloid extracted from the plant Gelsemium elegans. In previous research, Koumine...

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Bibliographic Details
Main Authors: Xiangyi Kong, Can Ning, Zengenni Liang, Chenglin Yang, You Wu, Yuanyuan Li, Aoao Wu, Yongkang Wang, Siqi Wang, Hui Fan, Wenguang Xiao, Jing Wu, Zhiliang Sun, Zhihang Yuan
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Koumine
Osteoarthritis
Extracellular matrix
Mitophagy
PINK1/Parkin
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224001549

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http://www.sciencedirect.com/science/article/pii/S0753332224001549

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