High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype classification

High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype classification

Abstract Background High-grade serous tubo-ovarian cancer (HGSTOC) is characterised by extensive inter- and intratumour heterogeneity, resulting in persistent therapeutic resistance and poor disease outcome. Molecular subtype classification based on bulk RNA sequencing facilitates a more accurate ch...

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Bibliographic Details
Main Authors: Siel Olbrecht, Pieter Busschaert, Junbin Qian, Adriaan Vanderstichele, Liselore Loverix, Toon Van Gorp, Els Van Nieuwenhuysen, Sileny Han, Annick Van den Broeck, An Coosemans, Anne-Sophie Van Rompuy, Diether Lambrechts, Ignace Vergote
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Genome Medicine
Subjects:
Single-cell RNA sequencing
High-grade serous tubo-ovarian cancer
Molecular subtypes
Stromal heterogeneity
Transcriptomic markers
Tumour microenvironment
Online Access:https://doi.org/10.1186/s13073-021-00922-x

Internet

https://doi.org/10.1186/s13073-021-00922-x

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