A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis

A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis

Summary: H2AX safeguards genomic stability in a dose-dependent manner; however, mechanisms governing its proteostasis are poorly understood. Here, we identify a PRMT5-RNF168-SMURF2 cascade that regulates H2AX proteostasis. We show that PRMT5 sustains the expression of RNF168, an E3 ubiquitin ligase...

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Bibliographic Details
Main Authors: Changzheng Du, Landon J. Hansen, Simranjit X. Singh, Feiyifan Wang, Ran Sun, Casey J. Moure, Kristen Roso, Paula K. Greer, Hai Yan, Yiping He
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719310654

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http://www.sciencedirect.com/science/article/pii/S2211124719310654

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