DNA Methylation Episignatures in Neurodevelopmental Disorders Associated with Large Structural Copy Number Variants: Clinical Implications

DNA Methylation Episignatures in Neurodevelopmental Disorders Associated with Large Structural Copy Number Variants: Clinical Implications

Large structural chromosomal deletions and duplications, referred to as copy number variants (CNVs), play a role in the pathogenesis of neurodevelopmental disorders (NDDs) through effects on gene dosage. This review focuses on our current understanding of genomic disorders that arise from large stru...

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Bibliographic Details
Main Authors: Kathleen Rooney, Bekim Sadikovic
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
DNA methylation
episignature
epigenetics
copy number variant
neurodevelopmental disorder
genomic disorder
Online Access:https://www.mdpi.com/1422-0067/23/14/7862

Internet

https://www.mdpi.com/1422-0067/23/14/7862

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