<i>C9orf72</i> Toxic Species Affect ArfGAP-1 Function

<i>C9orf72</i> Toxic Species Affect ArfGAP-1 Function

Compelling evidence indicates that defects in nucleocytoplasmic transport contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). In particular, hexanucleotide (G4C2) repeat expansions in <i>C9orf72</i>, the most common cause of genetic ALS, have a widespread impact on the...

Full description

Bibliographic Details
Main Authors: Simona Rossi, Michela Di Salvio, Marilisa Balì, Assia De Simone, Savina Apolloni, Nadia D’Ambrosi, Ivan Arisi, Francesca Cipressa, Mauro Cozzolino, Gianluca Cestra
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
amyotrophic lateral sclerosis
<i>C9orf72</i>
<i>Drosophila melanogaster</i>
Golgi-to-ER trafficking
ArfGAP-1
Online Access:https://www.mdpi.com/2073-4409/12/15/2007

Internet

https://www.mdpi.com/2073-4409/12/15/2007

Similar Items