BMP2K dysregulation promotes abnormal megakaryopoiesis in acute megakaryoblastic leukemia

BMP2K dysregulation promotes abnormal megakaryopoiesis in acute megakaryoblastic leukemia

Abstract Background Forced polyploidization is an effective strategy for acute megakaryoblastic leukemia (AMKL) therapy and factors controlling polyploidization are potential targets for drug development. Although bone morphology protein 2-inducible kinase (BMP2K) has been implied to be a potential...

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Bibliographic Details
Main Authors: Manman Wang, Tan Zhang, Xuechun Zhang, Zhou Jiang, Min Peng, Zan Huang
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Cell & Bioscience
Subjects:
BMP2K
AMKL
Megakaryocytes
Polyploidization
Differentiation
CDK2
Online Access:http://link.springer.com/article/10.1186/s13578-020-00418-y

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http://link.springer.com/article/10.1186/s13578-020-00418-y

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