AKR1A1 Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity

AKR1A1 Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity

Schizophrenia is a heterogeneous psychiatric disorder characterized by positive symptoms such as hallucinations and delusions, negative symptoms such as anhedonia and flat affect, and cognitive impairment. Recently, glucuronate (GlucA) levels were reported to be significantly higher in serum of pati...

Full description

Bibliographic Details
Main Authors: Kyoka Iino, Kazuya Toriumi, Riko Agarie, Mitsuhiro Miyashita, Kazuhiro Suzuki, Yasue Horiuchi, Kazuhiro Niizato, Kenichi Oshima, Atsushi Imai, Yukihiro Nagase, Itaru Kushima, Shinsuke Koike, Tempei Ikegame, Seiichiro Jinde, Eiichiro Nagata, Shinsuke Washizuka, Toshio Miyata, Shunya Takizawa, Ryota Hashimoto, Kiyoto Kasai, Norio Ozaki, Masanari Itokawa, Makoto Arai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Genetics
Subjects:
aldo-keto reductase family 1 member A1
treatment-resistant schizophrenia
single nucleotide variant (SNV)
exon skipping
frameshift mutation
glucuronate
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.762999/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.762999/full

Similar Items