ZNF117 regulates glioblastoma stem cell differentiation towards oligodendroglial lineage

ZNF117 regulates glioblastoma stem cell differentiation towards oligodendroglial lineage

Improved treatment of glioblastoma (GBM) can be achieved by inducing differentiation of glioblastoma stem cells (GSCs). Here, the authors show that zinc finger protein 117 (ZNF117) is a regulator of GSC differentiation via Notch signaling through interaction with JAG2, and can be targeted for therap...

Full description

Bibliographic Details
Main Authors: Jun Liu, Xiaoying Wang, Ann T. Chen, Xingchun Gao, Benjamin T. Himes, Hongyi Zhang, Zeming Chen, Jianhui Wang, Wendy C. Sheu, Gang Deng, Yang Xiao, Pan Zou, Shenqi Zhang, Fuyao Liu, Yong Zhu, Rong Fan, Toral R. Patel, W. Mark Saltzman, Jiangbing Zhou
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29884-3

Internet

https://doi.org/10.1038/s41467-022-29884-3

Similar Items