ALKBH5 regulates STAT3 activity to affect the proliferation and tumorigenicity of osteosarcoma via an m6A-YTHDF2-dependent manner

Summary: Background: N6-methyladenosine (m6A) is the most common and abundant mRNA modification and it plays crucial roles in many biological processes. However, as a key RNA demethylase, alkylation repair homolog protein 5 (ALKBH5) has not been well studied in human osteosarcoma. The present study...

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Bibliographic Details
Main Authors: Zechuan Yang, Zhuo Cai, Caihong Yang, Zhengqiang Luo, Xing Bao
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:EBioMedicine
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422002031