A recombinant receptor-binding domain in trimeric form generates protective immunity against SARS-CoV-2 infection in nonhuman primates

A recombinant receptor-binding domain in trimeric form generates protective immunity against SARS-CoV-2 infection in nonhuman primates

Summary: A safe and effective vaccine is critical to combat the COVID-19 pandemic. Here, we developed a trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine candidate that simulates the natural structure of the spike (S) trimer glycoprotein. Immunization with the RBD trimer-induced robu...

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Bibliographic Details
Main Authors: Limin Yang, Deyu Tian, Jian-bao Han, Wenhui Fan, Yuan Zhang, Yunlong Li, Wenqiang Sun, Yanqiu Wei, Xiaodong Tian, Dan-dan Yu, Xiao-li Feng, Gong Cheng, Yuhai Bi, Yong-tang Zheng, Wenjun Liu
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:The Innovation
Subjects:
COVID-19
SARS-CoV-2
RBD
subunit vaccine
NHPs
variants
Online Access:http://www.sciencedirect.com/science/article/pii/S2666675821000655

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http://www.sciencedirect.com/science/article/pii/S2666675821000655

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