CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ

CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ

Abstract Dysregulated lineage commitment of mesenchymal stem cells (MSCs) contributes to impaired bone formation and an imbalance between adipogenesis and osteogenesis during skeletal aging and osteoporosis. The intrinsic cellular mechanism that regulates MSC commitment remains unclear. Here, we ide...

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Bibliographic Details
Main Authors: Ruiqi Yu, Hong Han, Shuxian Chu, Yijun Ding, Shiqi Jin, Yufeng Wang, Wei Jiang, Yuting Liu, Yongxin Zou, Molin Wang, Qiao Liu, Gongping Sun, Baichun Jiang, Yaoqin Gong
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-023-00263-y

Internet

https://doi.org/10.1038/s41413-023-00263-y

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