Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells

Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells

Summary: Endosomal Toll-like receptors (eTLRs) are essential for the sensing of non-self through RNA and DNA detection. Here, using spatiotemporal analysis of vesicular dynamics, super-resolution microscopy studies, and functional assays, we show that endomembrane defects associated with the deficie...

Full description

Bibliographic Details
Main Authors: Juan Yu, Elsa Meneses-Salas, Jennifer L. Johnson, Susanna Manenti, Mouad Ait Kbaich, Danni Chen, Kasra Askari, Jing He, Aparna Shukla, Binchu Shaji, Rosana Gonzalez-Quintial, Ben A. Croker, Jinzhong Zhang, Hal Hoffman, William B. Kiosses, Catherine Hedrick, Kersi Pestonjamasp, Nathan Wineinger, Roberto Baccala, Sergio D. Catz
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724009379

Internet

http://www.sciencedirect.com/science/article/pii/S2211124724009379

Similar Items