Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease

Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease

Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases: PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in cardiovascular disease. Here, we aimed to investigate the expression landscape and druggability potential of the entire PCSK fam...

Full description

Bibliographic Details
Main Authors: Bianca E. Suur, Melody Chemaly, Moritz Lindquist Liljeqvist, Djordje Djordjevic, Markus Stenemo, Otto Bergman, Eva Karlöf, Mariette Lengquist, Jacob Odeberg, Eva Hurt-Camejo, Per Eriksson, Daniel F.J. Ketelhuth, Joy Roy, Ulf Hedin, Michael Nyberg, Ljubica Matic
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
PCSK
vascular disease
carotid plaque
aortic aneurysm
therapeutic targeting
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.988561/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.988561/full

Similar Items