Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease

Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease

Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases: PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in cardiovascular disease. Here, we aimed to investigate the expression landscape and druggability potential of the entire PCSK fam...

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Bibliographic Details
Main Authors: Bianca E. Suur, Melody Chemaly, Moritz Lindquist Liljeqvist, Djordje Djordjevic, Markus Stenemo, Otto Bergman, Eva Karlöf, Mariette Lengquist, Jacob Odeberg, Eva Hurt-Camejo, Per Eriksson, Daniel F.J. Ketelhuth, Joy Roy, Ulf Hedin, Michael Nyberg, Ljubica Matic
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
PCSK
vascular disease
carotid plaque
aortic aneurysm
therapeutic targeting
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.988561/full

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