Rv0004 is a new essential member of the mycobacterial DNA replication machinery.

DNA replication is fundamental for life, yet a detailed understanding of bacterial DNA replication is limited outside the organisms Escherichia coli and Bacillus subtilis. Many bacteria, including mycobacteria, encode no identified homologs of helicase loaders or regulators of the initiator protein...

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Bibliographic Details
Main Authors: Katherine M Mann, Deborah L Huang, Anna J Hooppaw, Michelle M Logsdon, Kirill Richardson, Hark Joon Lee, Jacqueline M Kimmey, Bree B Aldridge, Christina L Stallings
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5720831?pdf=render