The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer’s disease

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer’s disease

Circadian behavioural deficits, including sleep irregularity and restlessness in the evening, are a distressing early feature of Alzheimer’s disease (AD). We have investigated these phenomena by studying the circadian behaviour of transgenic Drosophila expressing the amyloid beta peptide (Aβ). We fi...

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Bibliographic Details
Main Authors: Ko-Fan Chen, Bernard Possidente, David A. Lomas, Damian C. Crowther
Format: Article
Language:English
Published: The Company of Biologists 2014-04-01
Series:Disease Models & Mechanisms
Subjects:
Alzheimer’s disease
Circadian dysfunction
Non-cell-autonomous Aβ toxicity
Drosophila model
Biological clock
Online Access:http://dmm.biologists.org/content/7/4/445

Internet

http://dmm.biologists.org/content/7/4/445

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