Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.

Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.

We previously identified an association between a mismatch repair gene, MLH1, promoter SNP (rs1800734) and microsatellite unstable (MSI-H) colorectal cancers (CRCs) in two samples. The current study expanded on this finding as we explored the genetic basis of DNA methylation in this region of chromo...

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Bibliographic Details
Main Authors: Miralem Mrkonjic, Nicole M Roslin, Celia M Greenwood, Stavroula Raptis, Aaron Pollett, Peter W Laird, Vaijayanti V Pethe, Theodore Chiang, Darshana Daftary, Elizabeth Dicks, Stephen N Thibodeau, Steven Gallinger, Patrick S Parfrey, H Banfield Younghusband, John D Potter, Thomas J Hudson, John R McLaughlin, Roger C Green, Brent W Zanke, Polly A Newcomb, Andrew D Paterson, Bharati Bapat
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2954166?pdf=render

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http://europepmc.org/articles/PMC2954166?pdf=render

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