Human NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony

Human NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony

Summary: Anti-NMDA receptor autoantibodies (NMDAR-Abs) in patients with NMDAR encephalitis cause severe disease symptoms resembling psychosis and cause cognitive dysfunction. After passive transfer of patients’ cerebrospinal fluid or human monoclonal anti-GluN1-autoantibodies in mice, we find a disr...

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Bibliographic Details
Main Authors: Mihai Ceanga, Vahid Rahmati, Holger Haselmann, Lars Schmidl, Daniel Hunter, Anna-Katherina Brauer, Sabine Liebscher, Jakob Kreye, Harald Prüss, Laurent Groc, Stefan Hallermann, Josep Dalmau, Alessandro Ori, Manfred Heckmann, Christian Geis
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723011786

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http://www.sciencedirect.com/science/article/pii/S2211124723011786

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