Functional study of the Hap4-like genes suggests that the key regulators of carbon metabolism HAP4 and oxidative stress response YAP1 in yeast diverged from a common ancestor.

The transcriptional regulator HAP4, induced by respiratory substrates, is involved in the balance between fermentation and respiration in S. cerevisiae. We identified putative orthologues of the Hap4 protein in all ascomycetes, based only on a conserved sixteen amino acid-long motif. In addition to...

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Main Authors: Nataliya Petryk, You-Fang Zhou, Kateryna Sybirna, Marie-Hélène Mucchielli, Bernard Guiard, Wei-Guo Bao, Oleh V Stasyk, Olena G Stasyk, Olena S Krasovska, Karine Budin, Nancie Reymond, Sandrine Imbeaud, Sophie Coudouel, Hervé Delacroix, Andriy Sibirny, Monique Bolotin-Fukuhara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4257542?pdf=render