Computational analysis of benzyl vinylogous derivatives as potent PDE3B inhibitors

Computational analysis of benzyl vinylogous derivatives as potent PDE3B inhibitors

Phosphodiesterases are a diverse family of enzymes that play a key role in regulating intracellular levels of the second messengers cAMP, cGMP and ultimate cell function. Selective PDE3B inhibitors were recognized to prevent oocyte maturation. In search of effective PDE3B inhibitors, the present stu...

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Bibliographic Details
Main Authors: Shweta Jain, Ankur Vaidya, Abhishek Kumar Jain, Ram Kishore Agrawal, Sushil Kumar Kashaw
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Arabian Journal of Chemistry
Subjects:
3D QSAR
CoMFA
PLS
PDE3 inhibitors
Benzyl vinylogous
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535212001682

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http://www.sciencedirect.com/science/article/pii/S1878535212001682

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