Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation

Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation

Protein arginine methyltransferases (PRMTs) are required for the regulation of RNA processing factors. Type I PRMT enzymes catalyze mono- and asymmetric dimethylation; Type II enzymes catalyze mono- and symmetric dimethylation. To understand the specific mechanisms of PRMT activity in splicing regul...

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Bibliographic Details
Main Authors: Maxim I Maron, Alyssa D Casill, Varun Gupta, Jacob S Roth, Simone Sidoli, Charles C Query, Matthew J Gamble, David Shechter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
PRMT5
PRMT1
retained detained introns
RNA processing
snRNP
A549
Online Access:https://elifesciences.org/articles/72867

Internet

https://elifesciences.org/articles/72867

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