Synergistic anti-tumour activity of sorafenib in combination with pegylated resveratrol is mediated by Akt/mTOR/p70S6k-4EBP-1 and c-Raf7MEK/ERK signaling pathways

Synergistic anti-tumour activity of sorafenib in combination with pegylated resveratrol is mediated by Akt/mTOR/p70S6k-4EBP-1 and c-Raf7MEK/ERK signaling pathways

Introduction: To investigate the inhibitory effect of sorafenib combined with PEGylated resveratrol on renal cell carcinoma (RCC) and its potential mechanism. Methods: MTT assay was used to detect the inhibitory effects of PEGylated resveratrol and sorafenib alone or combination on proliferation of...

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Bibliographic Details
Main Authors: Ligang Wang, Hao Wu, Ying Wang, Songcheng Xu, Chen Yang, Tingting Zhang, Yang Liu, Fuwei Wang, Weinan Chen, Jianchun Li, Litao Sun
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Heliyon
Subjects:
Resveratrol
Sorafenib
Combination
Kidney cancer
Akt/mTOR/p70S6k-4EBP-1
c-Raf7MEK/ERK
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023063624

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http://www.sciencedirect.com/science/article/pii/S2405844023063624

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