Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers

The investigation deals with the influence of permeation of rutin from carboxymethyl cellulose gel through full-thickness pig ear skin by (S)- and (R)-alaptide as potential excipients. Alaptide, 8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, is the original Czech compound. By means of this rapid scre...

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Bibliographic Details
Main Authors: Aneta Cernikova, Radka Opatrilova, Pavel Bobal, Josef Jampilek
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2015-01-01
Series:ADMET and DMPK
Online Access:http://pub.iapchem.org/ojs/index.php/admet/article/view/155