Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers
The investigation deals with the influence of permeation of rutin from carboxymethyl cellulose gel through full-thickness pig ear skin by (S)- and (R)-alaptide as potential excipients. Alaptide, 8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, is the original Czech compound. By means of this rapid scre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Association of Physical Chemists (IAPC)
2015-01-01
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| Series: | ADMET and DMPK |
| Online Access: | http://pub.iapchem.org/ojs/index.php/admet/article/view/155 |
| _version_ | 1819292977102585856 |
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| author | Aneta Cernikova Radka Opatrilova Pavel Bobal Josef Jampilek |
| author_facet | Aneta Cernikova Radka Opatrilova Pavel Bobal Josef Jampilek |
| author_sort | Aneta Cernikova |
| collection | DOAJ |
| description | The investigation deals with the influence of permeation of rutin from carboxymethyl cellulose gel through full-thickness pig ear skin by (S)- and (R)-alaptide as potential excipients. Alaptide, 8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, is the original Czech compound. By means of this rapid screening it was found out that the permeation of rutin through the skin increased linearly with time and was enhanced by both enantiomers of alaptide: approx. 1.2-fold by (R)-alaptide and approx. 1.5-fold by (S)-alaptide. |
| first_indexed | 2024-12-24T04:03:06Z |
| format | Article |
| id | doaj.art-45c089abc7b641efb8c6537d7dffb41a |
| institution | Directory Open Access Journal |
| issn | 1848-7718 |
| language | English |
| last_indexed | 2024-12-24T04:03:06Z |
| publishDate | 2015-01-01 |
| publisher | International Association of Physical Chemists (IAPC) |
| record_format | Article |
| series | ADMET and DMPK |
| spelling | doaj.art-45c089abc7b641efb8c6537d7dffb41a2022-12-21T17:16:15ZengInternational Association of Physical Chemists (IAPC)ADMET and DMPK1848-77182015-01-012424825310.5599/admet.2.4.155108Rapid Screening of Permeation of Rutin through Skin Using Alaptide EnantiomersAneta CernikovaRadka OpatrilovaPavel BobalJosef JampilekThe investigation deals with the influence of permeation of rutin from carboxymethyl cellulose gel through full-thickness pig ear skin by (S)- and (R)-alaptide as potential excipients. Alaptide, 8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, is the original Czech compound. By means of this rapid screening it was found out that the permeation of rutin through the skin increased linearly with time and was enhanced by both enantiomers of alaptide: approx. 1.2-fold by (R)-alaptide and approx. 1.5-fold by (S)-alaptide.http://pub.iapchem.org/ojs/index.php/admet/article/view/155 |
| spellingShingle | Aneta Cernikova Radka Opatrilova Pavel Bobal Josef Jampilek Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers ADMET and DMPK |
| title | Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers |
| title_full | Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers |
| title_fullStr | Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers |
| title_full_unstemmed | Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers |
| title_short | Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers |
| title_sort | rapid screening of permeation of rutin through skin using alaptide enantiomers |
| url | http://pub.iapchem.org/ojs/index.php/admet/article/view/155 |
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