Myeloid Pannexin-1 mediates acute leukocyte infiltration and leads to worse outcomes after brain trauma

Myeloid Pannexin-1 mediates acute leukocyte infiltration and leads to worse outcomes after brain trauma

Abstract Background Neuroinflammation is a major component of secondary damage after traumatic brain injury (TBI). We recently reported that pharmacological inhibition of Pannexin-1 (Panx1) channels markedly reduced the inflammatory response after TBI. Panx1 channels have been shown to be important...

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Bibliographic Details
Main Authors: Joon Ho Seo, Miloni S. Dalal, Frances Calderon, Jorge E. Contreras
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Neuroinflammation
Subjects:
Blood–brain barrier
Hemichannels
Inflammation
Pannexin
Traumatic brain injury
Online Access:http://link.springer.com/article/10.1186/s12974-020-01917-y

Internet

http://link.springer.com/article/10.1186/s12974-020-01917-y

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