Expression of Cyclin E1 in hepatic stellate cells is critical for the induction and progression of liver fibrosis and hepatocellular carcinoma in mice

Expression of Cyclin E1 in hepatic stellate cells is critical for the induction and progression of liver fibrosis and hepatocellular carcinoma in mice

Abstract Hepatocellular carcinoma (HCC) is one of the most severe malignancies with increasing incidence and limited treatment options. Typically, HCC develops during a multistep process involving chronic liver inflammation and liver fibrosis. The latter is characterized by the accumulation of extra...

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Main Authors: Julia Otto, Anna Verwaayen, Christian Penners, Jana Hundertmark, Cheng Lin, Carina Kallen, Daniela Paffen, Tobias Otto, Hilmar Berger, Frank Tacke, Ralf Weiskirchen, Yulia A. Nevzorova, Matthias Bartneck, Christian Trautwein, Roland Sonntag, Christian Liedtke
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06077-4

Internet

https://doi.org/10.1038/s41419-023-06077-4

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